Attachment to host cells or tissues is often the first step in the establishment of bacterial infections a complex array of recognition attachment and virulence factors is involved in this process which recent research has greatly illuminated. Little is known about adherence of normal microflora of healthy tissues most of the information which we know are on microbial adhesion between pathogenic microor ganisms and host cells several other facets to bacterial adhesion are given in fig 2714 fig 2714 facets of bacterial adhesion to host cells. Successful establishment of infection by bacterial pathogens requires adhesion to host cells colonization of tissues and in certain cases cellular invasion followed by intracellular multiplication dissemination to other tissues or persistence. The adhesion of bacteria to host cells is a critical event in the development of bacterial infections knowledge of the molecular mechanisms of this process is key to understanding an essential step in pathogenesis and to identifying potential targets for antimicrobial therapy
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